Autophagy-related 4

By Targets:	Atg8/LC3 (1) Autophagy (1) Dopamine Transporter (1) Serotonin Transporter (1)
By Research Areas:	Cancer (1) Neurological Disease (1)

Targets Recommended: Autophagy Interleukin Related Atg4 Atg8/LC3 Mas-related G-protein-coupled Receptor (MRGPR) AUTACs Mitophagy Trk Receptor ROR NEKs Kallikrein CGRP Receptor Arp2/3 Complex ATM/ATR sFRP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N4180

Pennogenin 3-O-beta-chacotrioside	Atg8/LC3 Autophagy	Cancer
Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla, modulates *autophagy* via increasing the expressions of autophagy-related proteins LC3 and Beclin-1. Anti-colorectal cancer activity .

HY-110019

Indatraline hydrochloride Lu 19-005	Serotonin Transporter Dopamine Transporter	Neurological Disease
Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine). Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride induces *autophagy* while simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis .

Cat. No.	Product Name

HY-L029

Autophagy Compound Library	1371 compounds
Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. MCE provides a unique collection of 1371 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.

Autophagy Compound Library

1371 compounds

Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease.

MCE provides a unique collection of 1371 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4180

Pennogenin 3-O-beta-chacotrioside	Structural Classification Liliaceae Classification of Application Fields Source classification Paris polyphylla Smith Plants Disease Research Fields Steroids Cancer	Atg8/LC3 Autophagy
Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla, modulates *autophagy* via increasing the expressions of autophagy-related proteins LC3 and Beclin-1. Anti-colorectal cancer activity .

Species:	Human (7)
Tag:	His (3) Tag Free (2) Myc (1) MBP (1) Flag (2)
Source:	HEK293 (2) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P71576

	ATG14 Protein, Human (Myc, His) 4832427M01; ATG14; Atg14L; Autophagy-related protein 14-like protein; Barkor; Beclin 1-associated Autophagy-related key regulator; D14Ertd114e	Human	E. coli
	ATG14 is critical for basal and induced autophagy, determining PI3KC3-C1 localization, helping autophagosome formation and BECN1 translocation. It enhances PIK3C3 activity in a BECN1-dependent manner, which is essential for BECN1 phosphorylation. ATG14 Protein, Human (Myc, His) is the recombinant human-derived ATG14 protein, expressed by E. coli , with C-Myc, N-10*His labeled tag. The total length of ATG14 Protein, Human (Myc, His) is 492 a.a., with molecular weight of ~70 kDa.

HY-P701246

	ATG10 Protein, Human (GST) Ubiquitin-Like-Conjugating Enzyme ATG10; Autophagy-related Protein 10; APG10-Like; ATG10	Human	E. coli
	ATG10 Protein, Human (GST) is a recombinant human Autophagy Related 10 Homolog (ATG10) expressed in E. coli with a GST tag. ATG10 is an E2 ubiquitin-conjugating-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation.

HY-P7617

	ATG3 Protein, Human rHuATG3; Ubiquitin-like-conjugating enzyme ATG3; Autophagy-related protein 3; APG3-like; ATG3; APG3; APG3L	Human	E. coli
	ATG3 Protein, Human is a recombinant human Ubiquitin-like-conjugating Enzyme ATG3 expressed in E. coli. ATG3, the E2 ubiquitin-conjugating enzyme for the LC3 lipidation process, is essential for autophagy.

HY-P70909

	MAP1LC3B Protein, Human Microtubule-associated proteins 1A/1B light chain 3B; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; MAP1A/MAP1B LC3 B; Microtubule-associated protein 1 light cha	Human	E. coli
	MAP1LC3B is a key ubiquitin-like modifier essential for the formation of autophagosome vacuoles, which maintains cellular homeostasis. In mitophagy, it regulates mitochondrial number, suppresses reactive oxygen species and ensures energy efficiency. MAP1LC3B Protein, Human is the recombinant human-derived MAP1LC3B protein, expressed by E. coli , with tag free. The total length of MAP1LC3B Protein, Human is 125 a.a., with molecular weight of ~16.15 kDa.

HY-P70916

	MAP1LC3A Protein, Human (His) Microtubule-Associated Proteins 1A/1B Light Chain 3A; Autophagy-related Protein LC3 A; Autophagy-related Ubiquitin-Like Modifier LC3 A; MAP1 Light Chain 3-Like Protein 1; MAP1A/MAP1B Light Chain 3 A; MAP1A/MAP1B LC3 A; Microtubule-Associated Protein 1 Light Cha	Human	E. coli
	MAP1LC3A is a key ubiquitin-like modifier essential for autophagosome vacuole formation, ensuring cellular homeostasis. As part of the GABARAP/GATE-16 subfamily, it plays a crucial role in late autophagosome maturation. MAP1LC3A Protein, Human (His) is the recombinant human-derived MAP1LC3A protein, expressed by E. coli , with C-6*His labeled tag. The total length of MAP1LC3A Protein, Human (His) is 121 a.a., with molecular weight of ~16.0 kDa.

HY-P701358

	ATG9B Protein, Human (HEK293, FLAG) ATG9B; Autophagy-related protein 9B; APG9-like 2; Nitric oxide synthase 3-overlapping antisense gene protein; Protein sONE	Human	HEK293
	ATG9B Protein, a phospholipid scramblase crucial for autophagy, dynamically cycles between the preautophagosomal structure (PAS) and the cytoplasmic vesicle pool. It plays a critical role in expanding autophagosomal membranes, facilitating lipid distribution with ATG2 and driving membrane expansion. Additionally, ATG9B participates in necrotic cell death. ATG9B Protein, Human (HEK293, FLAG) is the recombinant human-derived ATG9B protein, expressed by HEK293 , with C-Flag labeled tag. The total length of ATG9B Protein, Human (HEK293, FLAG) is 924 a.a., .

HY-P701359

	ATG9B Protein, Human (HEK293, His, MBP, FLAG) ATG9B; Autophagy-related protein 9B; APG9-like 2; Nitric oxide synthase 3-overlapping antisense gene protein; Protein sONE	Human	HEK293
	ATG9B Protein, a phospholipid scramblase crucial for autophagy, dynamically cycles between the preautophagosomal structure (PAS) and the cytoplasmic vesicle pool. It plays a critical role in expanding autophagosomal membranes, facilitating lipid distribution with ATG2 and driving membrane expansion. Additionally, ATG9B participates in necrotic cell death. ATG9B Protein, Human (HEK293, His, MBP, FLAG) is the recombinant human-derived ATG9B protein, expressed by HEK293 , with N-MBP, C-Flag, N-8*His labeled tag. The total length of ATG9B Protein, Human (HEK293, His, MBP, FLAG) is 924 a.a., .


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Application	Reactivity

HY-P80557

ATG4A Antibody ATG4A; APG4A; AUTL2; Cysteine protease ATG4A; AUT-like 2 cysteine endopeptidase; Autophagin-2; Autophagy-related cysteine endopeptidase 2; Autophagy-related protein 4 homolog A; hAPG4A	WB, IHC-P, IP	Human
ATG4A Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 45 kDa, targeting to ATG4A. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human .

HY-P80558

ATG4C Antibody ATG4C; APG4C; AUTL1; AUTL3; Cysteine protease ATG4C; AUT-like 3 cysteine endopeptidase; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C	WB, IHC-P	Human
ATG4C Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 52 kDa, targeting to ATG4C. It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P81905

ATG13 Antibody (YA1650)

Autophagy-related protein 13
WB, IP Human, Mouse, Rat

HY-P82723

ATG4B Antibody (YA2468) ATG4B; APG4B; AUTL1; KIAA0943; Cysteine protease ATG4B; AUT-like 1 cysteine endopeptidase; Autophagin-1; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B; hAPG4B	WB, FC	Human, Mouse, Rat

HY-P82442

ATG16L1 Antibody (YA2187)

ATG16L1; APG16L; Autophagy-related protein 16-1; APG16-like 1
WB Human, Mouse, Rat

HY-P83336

ATG9A Antibody (YA3081) ATG9A; APG9-like 1; Autophagy 9-like 1 protein; Autophagy-related protein 9A; MGD3208; MATG9; APG9 Autophagy 9-like 1; APG9L1; Autophagy related 9A	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

HY-P81236

ATG10 Antibody Autophagy related 10; APG10; APG10L; pp12616	WB；IHC	Human, Mouse
ATG10 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 25 kDa, targeting to ATG10. It can be used for WB,IHC assays with tag free, in the background of Human and mouse.

HY-P80555

ATG10 Antibody (YA603) Autophagy related 10; APG10; APG10L; pp12616	WB, IP	Human
ATG10 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 25 kDa, targeting to ATG10. It can be used for WB,IP assays with tag free, in the background of Human.

HY-P81226

LC3 Antibody Autophagy related protein LC3 A; Autophagy related protein LC3 B; Autophagy related ubiquitin like modifier LC3 A; Autophagy related ubiquitin like modifier LC3 B; MAP1 light chain 3 like protein 1; MAP1 light chain 3 like protein 2; MAP1A/1B light chain 3 A; MAP1A/1B light chain 3 B; MAP1A/1BLC3; MAP1A/MAP1B LC3 A; MAP1A/MAP1B LC3 B; MAP1ALC3; MAP1BLC3; MAP1LC3A; MAP1LC3B; Microtubule associated protein 1 light chain 3 alpha; Microtubule associated protein 1 light chain 3 beta; Microtubule associated proteins 1A/1B light chain 3; Microtubule associated proteins 1A/1B light chain 3A; Microtubule associated proteins 1A/1B light chain 3B; MLP3A_HUMAN.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Rat(predicted: Mouse, Chicken, Dog, Pig, Cow, Horse, Sheep, Goat)
LC3 Antibody is an unconjugated, approximately 14/16 kDa, rabbit-derived, anti-LC3 polyclonal antibody. LC3 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, rat, and predicted: mouse, chicken, dog, pig, cow, horse, sheep, goat background without labeling.

HY-P80545

APG5L Antibody APG 5L; APG5; APG5 Autophagy 5 like; APG5 like; APG5-like; Apoptosis specific protein; ASP; ATG 5; ATG5 Autophagy related 5 homolog; Autophagy protein 5; hAPG5	WB, ICC/IF, IP	Human, Mouse, Rat
APG5L Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 32 kDa, targeting to APG5L. It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Screening Libraries

Natural
Products

Recombinant Proteins

Antibodies